Analytical Data
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基因名
MAP4K4
- Application
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别名
MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4; FLH21957; hepatocyte progenitor kinase like/germinal center kinase like kinase; HGK; HPK/GCK like kinase; NIK
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种属
Human
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表达系统
Baculovirus
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标签
N-GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95819-1
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表达区间
A2-E328
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蛋白长度
Partial
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分子量
64.1 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4) is a member of the MAP4K family that plays a crucial role in various cellular processes, including cell growth, differentiation, and stress response. The research on MAP4K4 has garnered attention due to its involvement in several pathological conditions, such as cancer, obesity, and autoimmune diseases. It functions as a signaling mediator in the MAPK cascade, influencing downstream pathways that regulate cell survival and apoptosis. Dysregulation of MAP4K4 has been implicated in tumorigenesis, making it a potential biomarker and therapeutic target for cancer treatment. Recent studies have explored the molecular mechanisms underlying MAP4K4's role in promoting oncogenic pathways, as well as its interaction with other signaling molecules. Furthermore, the development of specific inhibitors targeting MAP4K4 offers promising avenues for therapeutic strategies. Understanding the intricate functions and regulatory mechanisms of MAP4K4 may provide insights into novel interventions for diseases associated with its dysregulation, paving the way for advancements in targeted therapies and personalized medicine.
