Analytical Data
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基因名
GSK3B
- Application
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别名
Serine/threonine-protein kinase GSK3B
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种属
Mouse
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q9WV60
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表达区间
Lys122~Thr375
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分子量
33kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GSK3B, or Glycogen Synthase Kinase 3 Beta, is a serine/threonine kinase that plays a critical role in various cellular processes, including metabolism, cell signaling, and apoptosis. It is part of the Wnt signaling pathway and is known for its involvement in the regulation of glycogen synthesis and the phosphorylation of numerous substrates, impacting cell growth and differentiation. Dysregulation of GSK3B is associated with a range of diseases, particularly in neurodegenerative conditions like Alzheimer's disease and various cancers. The study of recombinant GSK3B protein has become pivotal in understanding its function within these pathways and its potential as a therapeutic target. Recombinant GSK3B enables researchers to explore the biochemical properties of the enzyme, investigate its interactions with various substrates, and evaluate the effects of small molecule inhibitors. By generating GSK3B through recombinant DNA technology, scientists can more precisely delineate its role in disease mechanisms and facilitate the development of novel treatments aimed at modulating its activity, thus contributing to advancements in targeted therapies for complex diseases. The growing interest in GSK3B research underscores its significance in both basic biological research and clinical applications.
