Analytical Data
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Gene name
GSK3B
- Application
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Alternative Names
Serine/threonine-protein kinase GSK3B
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Species
Human
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Source
E. coli
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Tag
N-6His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
P49841
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Expression Region
122~375aa
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Molecular Weight
33kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Identification
Protein Description
GSK3B, or Glycogen Synthase Kinase 3 Beta, is a serine/threonine kinase that plays a critical role in various cellular processes, including metabolism, cell signaling, and apoptosis. It is part of the Wnt signaling pathway and is known for its involvement in the regulation of glycogen synthesis and the phosphorylation of numerous substrates, impacting cell growth and differentiation. Dysregulation of GSK3B is associated with a range of diseases, particularly in neurodegenerative conditions like Alzheimer's disease and various cancers. The study of recombinant GSK3B protein has become pivotal in understanding its function within these pathways and its potential as a therapeutic target. Recombinant GSK3B enables researchers to explore the biochemical properties of the enzyme, investigate its interactions with various substrates, and evaluate the effects of small molecule inhibitors. By generating GSK3B through recombinant DNA technology, scientists can more precisely delineate its role in disease mechanisms and facilitate the development of novel treatments aimed at modulating its activity, thus contributing to advancements in targeted therapies for complex diseases. The growing interest in GSK3B research underscores its significance in both basic biological research and clinical applications.
