Analytical Data
-
基因名
PTPRG
-
简介
PTPRG protein, also known as G-type protein tyrosine phosphatase receptor, is characterized by its tyrosine phosphatase activity. As a member of the protein tyrosine phosphatase (PTP) family, PTPRG is involved in the dephosphorylation of tyrosine residues in target proteins. PTPRG Protein, Human (His) is the recombinant human-derived PTPRG protein, expressed by E. coli , with N-6*His labeled tag.
- Application
-
别名
PTPRG; Receptor-type tyrosine-protein phosphatase gamma; Protein-tyrosine phosphatase gamma; R-PTP-gamma
-
种属
Human
-
表达系统
E. coli
-
标签
N-6*His
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P23470
-
表达区间
P820-N1130
-
蛋白长度
Partial
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PTPRG, or protein tyrosine phosphatase receptor-type G, is a member of the protein tyrosine phosphatase family, which plays a crucial role in regulating various cellular processes, including cell growth, differentiation, and signal transduction. Recent studies have highlighted the significance of PTPRG in tumorigenesis and its potential as a tumor suppressor, particularly in various cancers such as colorectal and breast cancer. Its expression is often downregulated in malignant tissues, suggesting a protective role against cancer progression. Research on PTPRG has expanded towards the exploration of its mechanisms of action, particularly through the study of its extracellular domain and potential ligands, which may provide insights into its role in cell signaling pathways. As a receptor-type phosphatase, PTPRG is known to interact with multiple signaling molecules, potentially affecting pathways like PI3K/Akt and Ras/MAPK. The generation of recombinant PTPRG proteins has been pivotal in these studies, allowing for detailed biochemical analyses and the examination of its phosphatase activity. Understanding the structure-function relationship of PTPRG through recombinant protein studies could pave the way for the development of novel therapeutic interventions targeting its pathway, offering hope for new cancer treatments. Overall, the research on PTPRG and its recombinant proteins serves to elucidate the complex biology of this phosphatase, contributing to the broader understanding of tumor biology and therapeutic strategies in oncology.
