Analytical Data
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Gene name
SENP5
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简介
The SENP5 protein is critical in the SUMO pathway and promotes the regulation of SUMOylation through two key functions. First, it processes full-length SUMO3 into its mature form, facilitating the maturation of this ubiquitin-like modifier. SENP5 Protein, Human (GST) is the recombinant human-derived SENP5 protein, expressed by E. coli , with N-GST labeled tag.
- Application
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Alternative Names
SENP5; Sentrin-specific protease 5; Sentrin/SUMO-specific protease SENP5
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Species
Human
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Source
E. coli
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Tag
N-GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96HI0
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Expression Region
D536-D755
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SENP5 (Sentrin-specific protease 5) is a member of the SUMO (Small Ubiquitin-like Modifier) protease family, which plays a crucial role in the post-translational modification of proteins through deSUMOylation. This process is vital for regulating various cellular functions, including signal transduction, DNA repair, and cell cycle control. Dysregulation of SENP5 has been implicated in several pathological conditions, including cancer, where it may contribute to tumor progression and metastasis by altering the stability and activity of key regulatory proteins. Due to its significant role in cellular homeostasis and disease pathology, SENP5 has garnered attention as a potential therapeutic target. The production and purification of recombinant SENP5 protein allow for extensive biochemical characterization and the exploration of its enzymatic functions, substrate specificity, and regulatory mechanisms. Such studies can reveal insights into the molecular basis of SENP5-related diseases and facilitate the development of novel therapeutic strategies aimed at modulating SENP5 activity for clinical benefit. Understanding the functional dynamics of SENP5 through recombinant protein studies is crucial for elucidating its role in SUMOylation pathways and may contribute to the development of targeted interventions in diseases characterized by aberrant SUMOylation processes.
