Analytical Data
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基因名
CDK2
- Application
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别名
CDKN2; p33(CDK2); Cell division protein kinase 2; p33 protein kinase
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P24941
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表达区间
Ser94~Thr198
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分子量
43kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Cyclin-dependent kinase 2 (CDK2) is a crucial enzyme that regulates the cell cycle and plays a vital role in cellular processes such as DNA replication and cell division. Its activity is primarily controlled by its association with cyclins and various regulatory proteins. Dysregulation of CDK2 has been implicated in numerous diseases, including cancer, where it can lead to uncontrolled cell proliferation. The study of recombinant CDK2 proteins is essential for understanding its biochemical properties, functional mechanisms, and interactions with inhibitors. Researchers have developed various recombinant forms of CDK2, facilitating studies on its catalytic activity and the effects of specific mutations. Additionally, the production of CDK2 as a recombinant protein allows for high-throughput screening of potential therapeutics aimed at modulating its activity. By investigating CDK2's structure-function relationship and its role in cancer biology, scientists aim to identify novel targets for cancer treatment and better understand the molecular pathways involved in tumorigenesis. Overall, the exploration of recombinant CDK2 offers significant insights into cell cycle regulation and potential strategies for therapeutic intervention in diseases associated with its dysregulation.
