Analytical Data
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基因名
SENP5
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简介
The SENP5 protein is critical in the SUMO pathway and promotes the regulation of SUMOylation through two key functions. First, it processes full-length SUMO3 into its mature form, facilitating the maturation of this ubiquitin-like modifier. SENP5 Protein, Human is the recombinant human-derived SENP5 protein, expressed by E. coli , with tag free.
- Application
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别名
SENP5; Sentrin-specific protease 5; Sentrin/SUMO-specific protease SENP5
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96HI0
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表达区间
D536-D755
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SENP5 (Sentrin-specific protease 5) is a member of the SUMO (Small Ubiquitin-like Modifier) protease family, which plays a crucial role in the post-translational modification of proteins through deSUMOylation. This process is vital for regulating various cellular functions, including signal transduction, DNA repair, and cell cycle control. Dysregulation of SENP5 has been implicated in several pathological conditions, including cancer, where it may contribute to tumor progression and metastasis by altering the stability and activity of key regulatory proteins. Due to its significant role in cellular homeostasis and disease pathology, SENP5 has garnered attention as a potential therapeutic target. The production and purification of recombinant SENP5 protein allow for extensive biochemical characterization and the exploration of its enzymatic functions, substrate specificity, and regulatory mechanisms. Such studies can reveal insights into the molecular basis of SENP5-related diseases and facilitate the development of novel therapeutic strategies aimed at modulating SENP5 activity for clinical benefit. Understanding the functional dynamics of SENP5 through recombinant protein studies is crucial for elucidating its role in SUMOylation pathways and may contribute to the development of targeted interventions in diseases characterized by aberrant SUMOylation processes.
