Analytical Data
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Gene name
KLF6
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简介
KLF6 Protein, a transcriptional activator, binds GC box motifs and may contribute to B-cell growth and development. It interacts with ZZEF1. KLF6 Protein, Human is the recombinant human-derived KLF6 protein, expressed by E. coli , with tag free.
- Application
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Species
Human
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q99612-3
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Expression Region
M1-S109
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Protein Length
Partial
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Molecular Weight
16.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KLF6 (Krüppel-like factor 6) is a member of the Krüppel-like factor family of zinc-finger transcription factors, which play crucial roles in various biological processes, including cell proliferation, differentiation, and apoptosis. The gene encoding KLF6 has been implicated in tumorigenesis, particularly in prostate and colorectal cancers, as it can function as a tumor suppressor. One of the notable features of KLF6 is its ability to undergo alternative splicing, leading to the generation of different isoforms that can have distinct, often opposing functions in cellular contexts. Research into KLF6 recombinant proteins has gained momentum in recent years, driven by the need to better understand the functional diversity of KLF6 isoforms and their roles in cancer biology. By producing and characterizing these recombinant proteins, researchers aim to elucidate the molecular mechanisms through which KLF6 affects gene expression and cellular behavior. Additionally, studying recombinant KLF6 proteins can provide insights into potential therapeutic strategies targeting KLF6 pathways in cancer. Understanding how KLF6 and its isoforms interact with other proteins and regulatory elements within the cell is essential for developing innovative approaches for cancer treatment and improving patient outcomes. As research progresses, KLF6 continues to be a promising target for innovative therapeutic interventions, emphasizing the importance of developing reliable recombinant protein systems for further investigations.
