Analytical Data
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基因名
MORF4L2
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简介
The MORF4L2 protein is an important component of the NuA4 histone acetyltransferase complex and promotes transcriptional activation by acetylating histones H4 and H2A. This modification alters nucleosome-DNA interactions and promotes interactions with other transcription-positive proteins. MORF4L2 Protein, Human (His) is the recombinant human-derived MORF4L2 protein, expressed by E. coli , with C-6*His labeled tag.
- Application
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别名
Mortality Factor 4-Like Protein 2; MORF-Related Gene X Protein; Protein MSL3-2; Transcription Factor-Like Protein MRGX; MORF4L2; KIAA0026; MRGX
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种属
Human
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表达系统
E. coli
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15014
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表达区间
M1-L288
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氨基酸序列
MSSRKQGSQPRGQQSAEEENFKKPTRSNMQRSKMRGASSGKKTAGPQQKNLEPALPGRWGGRSAENPPSGSVRKTRKNKQKTPGNGDGGSTSEAPQPPRKKRARADPTVESEEAFKNRMEVKVKIPEELKPWLVEDWDLVTRQKQLFQLPAKKNVDAILEEYANCKKSQGNVDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILLAHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLGYLHDFLKYLAKNSASLFTASDYKVASAEYHRKAL
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蛋白长度
Full Length
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分子量
33-36 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MORF4L2, a member of the MRG (MORF4-related gene) family, has emerged as a significant focus in cancer research due to its potential role in oncogenesis and tumor progression. This protein shares structural similarities with other MRG family members that are known to be involved in regulating gene expression and chromatin remodeling, suggesting that MORF4L2 may play a pivotal role in epigenetic modifications. Recent studies have indicated that MORF4L2 is overexpressed in various types of cancers, leading to speculation about its contribution to malignant transformation and tumor cell proliferation. The protein's interactions with chromatin-modifying complexes and transcription factors highlight its potential as a therapeutic target. Furthermore, understanding the molecular mechanisms by which MORF4L2 influences gene expression could reveal novel insights into cancer biology and progression. As researchers delve deeper into the functional characterization of recombinant MORF4L2, its interactions with other cellular pathways are under investigation, aiming to elucidate its precise role in tumorigenesis. This research could pave the way for the development of targeted therapies against cancers where MORF4L2 is implicated, making it a promising candidate for further exploration in the realm of cancer treatment and management.
