Analytical Data
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基因名
GSK3α
- Application
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别名
Serine/threonine-protein kinase GSK3A
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P49840
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表达区间
Gln115~Leu409
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分子量
54kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GSK3α (Glycogen Synthase Kinase 3 Alpha) is a serine/threonine kinase that plays a critical role in various cellular processes, including metabolism, cell proliferation, differentiation, and apoptosis. It is particularly well-known for its involvement in the Wnt signaling pathway, which is essential for embryonic development and cancer progression. Dysregulation of GSK3α has been associated with numerous diseases, including neurodegenerative disorders such as Alzheimer's disease and various types of cancer. Research into GSK3α recombinant protein has gained significant attention due to its potential as a therapeutic target. Understanding the structure and function of GSK3α can aid in the development of specific inhibitors that could modulate its activity in disease states. Additionally, studying GSK3α's interactions with other proteins and pathways provides insights into its multifaceted roles in cellular signaling. The production of recombinant GSK3α allows scientists to explore its enzymatic properties and regulatory mechanisms in a controlled environment. This research is crucial for elucidating the protein's function and its implications in health and disease, paving the way for innovative strategies in drug development targeting GSK3α-related disorders.
