Analytical Data
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Gene name
GDF-8
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简介
GDF-8 (Growth Differentiation Factor 8) functions as a specific negative regulator of skeletal muscle growth. It forms homodimers linked by disulfide bonds and inhibits WFIKKN2 activity through interaction. GDF-8 also interacts with FST3, playing a regulatory role in skeletal muscle growth modulation. GDF-8 Protein, Human (CHO) is the recombinant human-derived GDF-8 protein, expressed by CHO, with tag free.
- Application
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Alternative Names
Growth/differentiation factor 8; GDF-8; Myostatin; MSTN
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Species
Human
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Source
CHO
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O14793
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Expression Region
D267-S375
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Protein Length
Partial
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Molecular Weight
12 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GDF-8, also known as myostatin, is a member of the transforming growth factor-beta (TGF-β) superfamily and plays a crucial role in regulating muscle growth and development. Discovered initially in the late 1990s, GDF-8 functions primarily as a negative regulator of myogenesis, inhibiting muscle differentiation and growth. Its significance has been widely studied due to its potential implications in muscle-wasting diseases, age-related sarcopenia, and exercise physiology. High levels of myostatin are associated with reduced muscle mass, making it a target for therapeutic interventions aimed at enhancing muscle regeneration and combating muscle degeneration. Researchers have investigated the properties and mechanisms of GDF-8 through various recombinant protein studies, enabling deeper insights into its signaling pathways and biological functions. The recombinant form of GDF-8 has become an essential tool for elucidating its role in muscle biology, testing myostatin inhibitors, and exploring potential applications in regenerative medicine and sports science. Overall, understanding GDF-8’s role and developing strategies to modulate its activity could have significant benefits in treating muscle-related disorders and enhancing athletic performance.
