Analytical Data
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Gene name
SARM1
- Application
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Alternative Names
SARM1; Sterile Alpha And TIR Motif Containing 1; Sterile alpha and Armadillo repeat protein; Tir-1 homolog
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q6SZW1
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Expression Region
Ser387~Ser548
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Molecular Weight
39kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SARM1 (sterile alpha and TIR motif-containing protein 1) is a pivotal protein involved in the regulation of neuronal injury and degeneration, particularly in the context of peripheral nerve damage. As a member of the Toll/interleukin-1 receptor (TIR) superfamily, SARM1 plays a critical role in the axonal degeneration process following injury. Upon activation, SARM1 triggers a cascade of events leading to the disassembly of the axon, which ultimately results in neuronal cell death, posing significant implications for neurodegenerative diseases and peripheral neuropathies. Given its central role in these pathological processes, the study of SARM1 has garnered increasing interest in the field of neuroscience. Researchers aim to better understand its mechanism of action, interactions with other signaling pathways, and potential as a therapeutic target to prevent or mitigate neuronal loss. The recombinant expression of SARM1 protein allows for detailed biochemical studies and the assessment of its functional properties. By producing SARM1 in a controlled environment, scientists can investigate its structure-function relationships, delineate its role in axonal signaling, and explore the effects of genetic or pharmacological modulation. This research could ultimately pave the way for innovative treatments for conditions associated with nerve damage, offering hope for improved outcomes in patients suffering from such disorders.
