Analytical Data
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Gene name
BAFF/TNFSF13B
- Application
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Alternative Names
CD257; TNFSF13B; BLYS; TALL1; THANK; TNFSF20; ZTNF4; B lymphocyte stimulator; Tumor Necrosis Factor Ligand Superfamily Member 13B; Dendritic cell-derived TNF-like
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Species
Rat
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Source
E. coli
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Tag
Two N- s, His- & SUMO-
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
D3ZFD8
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Expression Region
Gln188~Leu324
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Molecular Weight
35kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
BAFF (B-cell activating factor) or TNFSF13B (Tumor Necrosis Factor Superfamily member 13B) is a crucial cytokine involved in the regulation of B-cell maturation, survival, and proliferation. It acts primarily through binding to its receptors, BR3, BAFF-R, and TACI, facilitating the development of the immune system and playing a pivotal role in humoral immunity. Dysregulation of BAFF levels has been implicated in various autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, where elevated BAFF levels contribute to the survival of autoreactive B cells. Due to its significant role in both health and disease, BAFF has emerged as a potential therapeutic target. The development of recombinant BAFF proteins has provided valuable tools for research purposes, allowing for a better understanding of its signaling pathways and biological functions. These recombinant proteins can be utilized in in vitro and in vivo studies to dissect the molecular mechanisms underpinning B-cell related disorders and to evaluate the efficacy of BAFF-targeted interventions. Furthermore, the characterization of BAFF's structure and interactions with its receptors can yield insights that may lead to novel therapies aimed at modulating immune responses in autoimmune conditions and enhancing vaccine efficacy. Thus, the study of recombinant BAFF/TNFSF13B proteins is fundamentally important for both basic immunology and the development of targeted treatments for B-cell-related diseases.
