Analytical Data
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Gene name
AMY2A
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简介
AMY2B is a hydrolytic enzyme secreted by the pancreas that can hydrolyze α- 1,4-glycosidic bond, belonging to α- Members of the amylase family. AMY2B plays an important role in digesting dietary starch, and inhibiting AMY2B can lead to a decrease in postprandial blood sugar levels. Therefore, by regulating α- Amylase activity to control blood sugar level has therapeutic significance for diabetes, obesity and other diseases. AMY2A Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived AMY2A protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
Pancreatic alpha-amylase; PA; 1,4-alpha-D-glucan glucanohydrolase
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Species
Rhesus Macaque
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
H9EX43
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Expression Region
Q16-L511
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Protein Length
Full Length of Mature Protein
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Amyloid beta (Aβ) peptides play a crucial role in the pathogenesis of Alzheimer's disease, and AMY2A (amyloid precursor protein) is implicated in the regulation of Aβ production. The recombinant protein AMY2A has garnered significant attention in research due to its potential use in understanding the mechanisms of amyloidogenesis and the development of therapeutic strategies aimed at mitigating neurodegeneration. Investigating the structure and function of AMY2A can provide insights into how mutations and post-translational modifications affect its role in Aβ processing. Moreover, developing recombinant AMY2A allows researchers to produce large quantities of the protein for biochemical assays and structural studies, paving the way for the identification of small molecules or antibodies that could modulate its activity. Furthermore, AMY2A research underscores the importance of protein interactions within the amyloid cascade, highlighting promising avenues for targeted treatments for Alzheimer's disease. As therapies aimed at modifying Aβ deposition move into clinical trials, understanding the role of AMY2A becomes increasingly critical for the advancement of treatments that may slow or halt the progression of this debilitating disease.
