Analytical Data
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基因名
Galectin-1/LGALS1
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简介
Galectin-1/LGALS1 is a lectin that binds β-galactoside and complex carbohydrates and regulates apoptosis, proliferation, and differentiation. It inhibits CD45 phosphatase activity, blocks Lyn kinase dephosphorylation, and induces T cell apoptosis. Galectin-1/LGALS1 Protein, Human (HEK293, hFc) is the recombinant human-derived Galectin-1/LGALS1 protein, expressed by HEK293, with N-hFc labeled tag.
- Application
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别名
Galectin-1; HLBP14; S-Lac lectin 1; LGALS1; GAL1; GBP; DKFZp686E23103; Galectin 1
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种属
Human
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表达系统
HEK293
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标签
N-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P09382
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表达区间
A2-D135
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蛋白长度
Full Length of Mature Protein
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分子量
48-55 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Galectin-1 (LGALS1) is a member of the galectin family of proteins that bind β-galactosides and play crucial roles in various biological processes, including cell-cell interactions, immune modulation, and tumor progression. Research has highlighted its significant involvement in both normal physiology and pathological conditions, such as cancer and autoimmune diseases. Galectin-1 is known to facilitate tumor growth and metastasis by promoting angiogenesis and evading immune surveillance, making it a potential target for therapeutic interventions. Additionally, its expression in various tissues and its secretion by both immune and non-immune cells underscore its pleiotropic effects on the immune system. The production and characterization of recombinant Galectin-1 protein are essential for advancing our understanding of its functional mechanisms and developing galectin-1-based therapies. By studying the protein's interactions with specific ligands and cells, researchers can elucidate its role in modulating immunological responses and tumor microenvironments. Overall, the exploration of Galectin-1 as a biomolecule provides promising insights into novel treatment strategies for diverse diseases, underlining the importance of continued research in this area.
