Analytical Data
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Gene name
Galectin-1/LGALS1
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简介
Galectin-1/LGALS1 is a lectin that binds β-galactoside and complex carbohydrates and regulates apoptosis, proliferation, and differentiation. It inhibits CD45 phosphatase activity, blocks Lyn kinase dephosphorylation, and induces T cell apoptosis. Galectin-1/LGALS1 Protein, Human (HEK293, hFc) is the recombinant human-derived Galectin-1/LGALS1 protein, expressed by HEK293, with N-hFc labeled tag.
- Application
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Alternative Names
Galectin-1; HLBP14; S-Lac lectin 1; LGALS1; GAL1; GBP; DKFZp686E23103; Galectin 1
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Species
Human
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Source
HEK293
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Tag
N-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P09382
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Expression Region
A2-D135
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Protein Length
Full Length of Mature Protein
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Molecular Weight
48-55 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Galectin-1 (LGALS1) is a member of the galectin family of proteins that bind β-galactosides and play crucial roles in various biological processes, including cell-cell interactions, immune modulation, and tumor progression. Research has highlighted its significant involvement in both normal physiology and pathological conditions, such as cancer and autoimmune diseases. Galectin-1 is known to facilitate tumor growth and metastasis by promoting angiogenesis and evading immune surveillance, making it a potential target for therapeutic interventions. Additionally, its expression in various tissues and its secretion by both immune and non-immune cells underscore its pleiotropic effects on the immune system. The production and characterization of recombinant Galectin-1 protein are essential for advancing our understanding of its functional mechanisms and developing galectin-1-based therapies. By studying the protein's interactions with specific ligands and cells, researchers can elucidate its role in modulating immunological responses and tumor microenvironments. Overall, the exploration of Galectin-1 as a biomolecule provides promising insights into novel treatment strategies for diverse diseases, underlining the importance of continued research in this area.
