Analytical Data
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基因名
Cellular tumor antigen P53/TP53
- Application
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别名
(Antigen NY-CO-13)(Phosphoprotein p53)(Tumor suppressor p53)
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种属
Human
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表达系统
Baculovirus
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标签
C- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P04637
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表达区间
1-393aa(Y220C)
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分子量
49.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Cellular tumor antigen P53, also known as TP53, is a crucial tumor suppressor protein encoded by the TP53 gene. It plays a pivotal role in maintaining genomic stability by regulating the cell cycle, facilitating DNA repair, and inducing apoptosis in response to cellular stress or DNA damage. Mutations in the TP53 gene are commonly associated with various cancers, making it one of the most studied genes in oncology. The understanding of TP53’s structure and function has paved the way for developing therapeutic strategies targeting the p53 pathway. Researchers often utilize recombinant proteins of TP53 to investigate its biochemical properties, interactions with other cellular proteins, and response to various stimuli. The study of recombinant TP53 protein is critical in developing novel cancer therapies, including gene therapy and small molecule drugs aimed at restoring p53 function in tumors with mutated TP53. Additionally, the expression and functional analysis of recombinant p53 can aid in designing targeted delivery systems and understanding the protein’s role in tumorigenesis and as a potential biomarker for cancer diagnosis and prognosis. Overall, the investigation of recombinant TP53 protein is essential for unraveling its complex biology and therapeutic potential in cancer treatment.
