Analytical Data
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基因名
Tnnt2
- Application
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别名
CMH2; cTnT; TnTc; Cardiomyopathy,Hypertrophic 2; Cardiac muscle troponin T
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P45379
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表达区间
Met1~Lys295
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分子量
56kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Tnnt2, or cardiac troponin T, is a crucial protein involved in the regulation of cardiac muscle contraction. It forms part of the troponin complex, which plays a key role in the calcium-mediated mechanism of muscle contraction and relaxation in the heart. Studies have shown that mutations in the TNNT2 gene can lead to various forms of inherited cardiomyopathies, such as hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM), which are significant causes of heart failure and sudden cardiac death. The ability to produce recombinant Tnnt2 protein has significant implications for research and therapeutic applications, as it allows for the in-depth study of the protein's structure-function relationships and the effects of pathogenic mutations. Additionally, recombinant Tnnt2 can be used to develop diagnostic tools for early detection of cardiac conditions and to evaluate the efficacy of new drugs targeting troponin in disease management. The exploration of Tnnt2 through recombinant protein technology is therefore vital for understanding cardiac physiology, elucidating disease mechanisms, and advancing the field of cardiac medicine.
