Analytical Data
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Gene name
NME1/NDPKA
- Application
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Alternative Names
AWD; GAAD; NDPKA; NM23-H1; Nucleoside diphosphate kinase A; Granzyme A-activated DNase; Metastasis inhibition factor nm23; Tumor metastatic process-associated protein
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
P15531
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Expression Region
Met1~Glu152
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Molecular Weight
22kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NME1, also known as non-metastatic cells 1, is a member of the nucleoside diphosphate kinase (NDPK) family, which plays a crucial role in cellular metabolism by catalyzing the conversion of nucleoside diphosphates into nucleoside triphosphates. The NME1/NDPKA gene has garnered significant attention due to its association with various biological processes, including cell proliferation, differentiation, and metastasis, particularly in cancer research. Studies have linked NME1 expression levels with metastatic potential in several tumors, suggesting its potential as a biomarker for cancer progression. Furthermore, recent investigations have revealed that NME1/NDPKA may influence signaling pathways related to DNA repair and apoptosis, adding new dimensions to its functional repertoire. The recombinant expression of NME1/NDPKA protein facilitates an in-depth exploration of its biochemical properties and interactions with other cellular components, making it a valuable system for elucidating its mechanisms of action. Understanding these aspects could pave the way for novel therapeutic strategies targeting tumor metastasis and enhancing our comprehension of NME1's role in human health and disease.
