Analytical Data
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Gene name
GSTP1
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简介
Glutathione S-transferase P (GSTP1) is a member of GSTs family and plays an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. GSTP1 enables JUN kinase binding activity; glutathione transferase activity; and kinase regulator activity and is involved in negative regulation of cell population proliferation, intracellular signal transduction and macromolecule metabolic process as well. GSTP1 Protein, Human is the recombinant human-derived GSTP1 protein, expressed by E. coli , with tag free.
- Application
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Alternative Names
rHuGlutathione S-transferase P/GSTP1; Glutathione S-transferase P; GSTP1; GST class-pi; GSTP1-1; FAEES3; GST3;
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Species
Human
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
AAH10915.1
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Expression Region
M1-Q210
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AA Sequence
MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYVSLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ
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Protein Length
Full Length
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Molecular Weight
22-25 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GSTP1 (Glutathione S-Transferase Pi 1) is a member of the glutathione S-transferase (GST) family, which plays a crucial role in cellular detoxification processes by catalyzing the conjugation of glutathione to a variety of toxic compounds, including xenobiotics and endogenous metabolites. Research into GSTP1 has gained significant attention due to its involvement in drug metabolism, cancer progression, and resistance to chemotherapy. Elevated levels of GSTP1 have been detected in various cancers, making it a potential biomarker for tumor diagnosis and prognosis. Moreover, its role in protecting cells from oxidative stress implicates GSTP1 in various pathological conditions, including neurodegenerative diseases and inflammatory disorders. The recombinant expression of GSTP1 allows for detailed studies into its enzymatic function, structure, and interaction with substrates and inhibitors, facilitating the development of GSTP1-targeted therapeutics. Understanding the mechanisms by which GSTP1 contributes to drug resistance and cancer biology is critical for improving treatment strategies and patient outcomes in cancer therapy.
