Analytical Data
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Gene name
Annexin A1/ANXA1
- Application
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Alternative Names
ANX-A1; ANX1; LPC1; Lipocortin I; Chromobindin-9; Calpactin II; Phospholipase A2 inhibitory protein
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Species
Rabbit
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P51662
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Expression Region
Lys214~Ala341
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Molecular Weight
20kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Annexin A1 (ANXA1) is a 37-kDa protein that plays a crucial role in various cellular processes, particularly in the regulation of inflammation and the immune response. It is part of the annexin family of proteins, which are known for their ability to bind to phospholipids in a calcium-dependent manner. Research has shown that ANXA1 is involved in the modulation of glucocorticoid signaling, apoptosis, and cell migration. Its anti-inflammatory properties have made it a target of interest for therapeutic applications, especially in conditions such as asthma, arthritis, and other inflammatory diseases. Recombinant ANXA1 protein has been produced to study its structural and functional characteristics, as well as its interactions with other biomolecules. This recombinant form facilitates the investigation of the protein's mechanism of action and its potential as a therapeutic agent. Furthermore, understanding the role of ANXA1 in cellular pathways has implications for the development of novel treatments aimed at controlling excessive inflammation and promoting resolution, highlighting its significance in both basic research and clinical applications.
