Analytical Data
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Gene name
HSCB
- Application
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Alternative Names
DNAJC20; HSC20
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Species
Human
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Source
E. coli
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Tag
Strep;His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8IWL3
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Expression Region
M1-L235
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Protein Length
Full Length
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HSCB, or Heat Shock Cognate Protein B, is a crucial molecular chaperone that plays a significant role in protein folding and cellular stress responses. Its primary function involves assisting in the proper folding of nascent proteins and the refolding of misfolded proteins, thereby preventing aggregation and promoting cellular homeostasis. The study of HSCB is particularly important in the context of various diseases, including neurodegenerative disorders and cancers, where protein misfolding and aggregation are common pathological features. Researchers have focused on the recombinant production of HSCB to gain insights into its structure-function relationship, investigate its interaction with other cellular components, and assess its potential as a therapeutic target. Recombinant proteins allow for detailed biophysical characterization and functional studies, which are essential for understanding the molecular mechanisms underlying HSCB's role in stress responses. Additionally, the development of HSCB-based therapeutics could pave the way for novel treatment strategies aimed at mitigating the detrimental effects of protein misfolding in affected cells. As a result, ongoing research into the recombinant expression and functional analysis of HSCB is vital to broaden our understanding of protein homeostasis and to explore new avenues for intervention in human diseases associated with proteostasis failure.
