Analytical Data
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基因名
DCAF4
- Application
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别名
WDR21; WDR21A
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种属
Human
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表达系统
Baculovirus
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标签
N-His;N-Strep
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WV16-1
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表达区间
N2-S495
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DCAF4 (DDB1/CUL4-associated factor 4) is a crucial component of the CUL4-DDB1 E3 ubiquitin ligase complex, which plays an essential role in regulating various cellular processes, including cell cycle progression, DNA repair, and the response to oxidative stress. The function of DCAF4 is primarily mediated through its interaction with specific substrate proteins, facilitating their ubiquitination and subsequent proteasomal degradation. Recent studies have highlighted the significance of DCAF4 in maintaining cellular homeostasis and its potential implications in oncogenesis, as aberrations in the ubiquitination process are often linked to cancer development. Furthermore, DCAF4 has been identified as a critical regulator of the cellular response to DNA damage, contributing to the repair mechanisms that preserve genomic integrity. Understanding the structural and functional dynamics of DCAF4, particularly through the analysis of its recombinant protein, could unveil new therapeutic avenues for targeting diseases driven by dysregulated protein homeostasis. This research background emphasizes the necessity of exploring DCAF4's molecular mechanisms and its role in broader biological contexts, making it a compelling target for further investigation in cancer biology and therapeutic development.
