Analytical Data
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基因名
THOP1
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简介
THOP1 protein plays a key role in the metabolism of neuropeptides with less than 20 amino acids and participates in the degradation of cytoplasmic peptides. In addition to general peptide metabolism, THOP1 degrades amyloid beta precursor protein, implicating it in neurodegenerative diseases. THOP1 Protein, Mouse (sf9, His) is the recombinant mouse-derived THOP1 protein, expressed by Sf9 insect cells , with N-His labeled tag.
- Application
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别名
Thimet Oligopeptidase; Endopeptidase 24.15; MP78; THOP1
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种属
Mouse
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表达系统
Baculovirus
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8C1A5
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表达区间
K2-C687
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蛋白长度
Partial
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分子量
75 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
THOP1, or Thimet Oligopeptidase 1, is a metalloendopeptidase that plays a crucial role in various biological processes, including the degradation of bioactive peptides and the regulation of neuropeptide activity. Research on THOP1 has gained momentum due to its association with several physiological and pathological conditions, such as neurodegenerative diseases and cancer. Its enzymatic function is essential for maintaining the balance of peptide signaling in the brain, impacting neuronal communication and potentially influencing cognitive functions and behavior. Additionally, THOP1 has been implicated in the immune response and inflammation, revealing its broader significance in health and disease. The study of recombinant THOP1 has provided insights into its structural and functional properties, paving the way for therapeutic applications and the development of specific inhibitors. Understanding THOP1 at the molecular level could lead to novel strategies for treating disorders linked to peptide dysregulation, highlighting its importance in both fundamental research and clinical contexts. Overall, THOP1 represents a valuable target for investigations aimed at unraveling complex biochemical pathways and developing innovative treatment modalities.
