Analytical Data
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基因名
ATG7
- Application
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别名
APG7L; GSA7; Ubiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; Ubiquitin-activating enzyme E1-like protein
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95352
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表达区间
Asn387~Gln570
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分子量
24kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ATG7, or autophagy-related protein 7, is a crucial component of the autophagy pathway, a cellular degradation process that maintains homeostasis by removing damaged organelles and misfolded proteins. Dysfunction in autophagy is linked to various diseases, including neurodegenerative disorders, cancer, and infections, making ATG7 a significant target for therapeutic intervention. Research on ATG7 recombinant protein has gained momentum due to its vital role in the conjugation of ATG12 to ATG5, a critical step in autophagosome formation. By understanding the structure and function of ATG7, scientists aim to elucidate its regulatory mechanisms and interactions with other autophagy-related proteins, paving the way for novel strategies to manipulate autophagy in disease contexts. Moreover, the production of ATG7 as a recombinant protein allows for detailed biochemical studies, structural analysis, and potential drug screening applications, further highlighting its importance in both basic and applied research. Overall, the exploration of ATG7 and its role in autophagy could provide insights into cellular health and disease, offering pathways for innovative therapeutic approaches.
