Analytical Data
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基因名
Annexin A2/ANXA2
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简介
Annexin A2/ANXA2 Protein, Human is a 38kDa multifunctional protein which belongs to the annexin family. Annexin A2 is important for the regulation in the cellular growth and in signal transduction pathways. Annexin A2 also can be used as an autocrine factor that can heighten osteoclast formation and bone resorption[1].
- Application
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生物活性
Measured in a cell proliferation assay using A549 cells. The ED50 this effect is ≤1.051 ng/mL, corresponding to a specific activity is ≥9.515×105 units/mg. Measured in a cell proliferation assay using A549 cells. The The ED50 for this effect is 0.7184 ng/mL, corresponding to a specific activity is 1.39×106 units/mg.
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别名
rHuAnnexin A2; ANXA2; Annexin A2
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P07355-1
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表达区间
S2-D339
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氨基酸序列
STVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD
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蛋白长度
Full Length of Isoform-1 Mature Protein
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分子量
38 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Annexin A2 (ANXA2) is a multifunctional protein that plays a crucial role in various cellular processes, including cell adhesion, migration, and signaling. As a member of the annexin family, ANXA2 is known for its calcium-dependent binding to phospholipids, which is instrumental in cellular responses to environmental stress and injury. Its involvement in pathological conditions, such as cancer, inflammation, and cardiovascular diseases, has necessitated extensive research into its biological functions and mechanisms. Recombinant ANXA2 proteins have been developed to facilitate studies on protein interactions and functional assays, providing insights into how ANXA2 contributes to cellular dynamics under normal and pathological conditions. The generation of these recombinant proteins allows researchers to explore the structural and functional attributes of ANXA2 in vitro and in vivo, leading to a better understanding of its role in disease processes. Furthermore, the potential therapeutic applications of targeting ANXA2 in treating various conditions highlight the importance of continued research in this area. Overall, the study of recombinant ANXA2 proteins represents a significant advancement in elucidating the complexities of cellular functions and the potential for novel therapeutic strategies.
