Analytical Data
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Gene name
KCC3
- Application
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Alternative Names
SLC12A6; ACCPN; Solute Carrier Family 12 Member 6,Potassium/Chloride Transporters; Agenesis Of Corpus Callosum And Peripheral Neuropathy; K-Cl cotransporter 3
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q9UHW9
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Expression Region
Glu559~Ser735
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Molecular Weight
49.9kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KCC3 (potassium-chloride co-transporter 3) is an essential protein that plays a critical role in maintaining cellular ion homeostasis, particularly in the regulation of intracellular chloride levels. Its dysregulation has been implicated in various physiological and pathological conditions, including neurological disorders and hypertension. The study of KCC3 has gained attention due to its involvement in the processes of neurotransmission and neuronal excitability, making it a potential target for therapeutic intervention in conditions such as epilepsy and cognitive impairments. The reconstitution of KCC3 as a recombinant protein allows researchers to investigate its functional characteristics, regulatory mechanisms, and interactions with other proteins in a controlled environment. This approach provides insights into how KCC3 operates at the molecular level, enabling the identification of potential modulators that could influence its activity. Furthermore, understanding the structure-function relationships of KCC3 may aid in the development of specific inhibitors or activators that could be useful in clinical applications. As research progresses, the characterization of KCC3 in the context of its role in ion transport and homeostasis continues to unveil its significance in both health and disease, highlighting the need for further investigation into its therapeutic potential.
