Analytical Data
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基因名
Aminopeptidase P1
- Application
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别名
Aminoacylproline aminopeptidaseCytosolic aminopeptidase PSoluble aminopeptidase P ;sAmpX-Pro aminopeptidase 1X-prolyl aminopeptidase 1, soluble
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NQW7
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表达区间
2-623aa
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分子量
85.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Aminopeptidase P1 (AP-P1) is a pivotal enzyme involved in the metabolism of biologically active peptides, particularly in the hydrolysis of N-terminal amino acids. The enzyme plays an essential role in various physiological processes, including blood pressure regulation and neurotransmitter activity, by modulating peptide levels in the body. Dysregulation of aminopeptidase P has been implicated in several pathological conditions, including hypertension and neurodegenerative diseases. Recent advancements in genetic engineering and recombinant protein technology have enabled the production of AP-P1 in heterologous systems, providing insights into its structure-function relationships and catalytic mechanisms. The recombinant version of this protein has been instrumental in studying its kinetic properties, substrate specificity, and potential as a therapeutic target. Understanding the molecular dynamics of AP-P1 may pave the way for the design of specific inhibitors or modulators that could have significant implications for treating diseases associated with peptide metabolism. Furthermore, the characterization of recombinant AP-P1 can contribute to developing diagnostic tools for monitoring related health conditions. This research holds the promise for not only elucidating the biological roles of AP-P1 but also enhancing our capability to manipulate it for therapeutic benefits.
