Analytical Data
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Gene name
KIRREL3/NEPH2
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简介
The KIRREL3/NEPH2 protein plays a critical role in the formation of precise synapses, particularly in hippocampal mossy fiber synapses, where it is responsible for coordinating mossy fiber filopodia. It acts in a homologous manner to stabilize filopodia contacts and facilitate subsequent synapse formation. KIRREL3/NEPH2 Protein, Rat (HEK293, His) is the recombinant rat-derived KIRREL3/NEPH2 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Kin of IRRE-like protein 3; Nephrin-like protein 2; Kiaa1867; Neph2
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Species
Rat
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Source
HEK293
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Tag
C-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q09GS6
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Expression Region
L22-A523
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AA Sequence
LQRRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVVSGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPIILGGPVISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNIVTFHCSAKANPAVTQYRWAKRGHIIKEASGELYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTSEPQSLLVDLGSDAVFSCAWIGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETVNTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQESVPMA
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Protein Length
Partial
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Molecular Weight
60-80 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KIRREL3, also known as NEPH2, is a member of the nephrin-like family of proteins that play a crucial role in the development and function of the kidney and nervous system. It is a cell adhesion molecule primarily expressed in podocytes, specialized kidney cells essential for maintaining the glomerular filtration barrier. The importance of KIRREL3/NEPH2 is underscored by its involvement in various pathological conditions, including nephrotic syndrome and other renal diseases. Recent studies have highlighted its role in neuronal development and synaptic functions, suggesting that it also contributes to the nervous system's architecture. The recombinant protein of KIRREL3/NEPH2 is synthesized to facilitate in-depth studies of its biochemical properties and interactions with other cellular components. By producing this recombinant protein, researchers can explore its structural characteristics, functional roles, and potential as a therapeutic target. Investigations into KIRREL3/NEPH2 not only enhance our understanding of kidney function and development but also provide insights into neurodevelopmental processes, thereby opening avenues for innovative treatments for kidney disorders and neurological conditions associated with its dysregulation.
