Analytical Data
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Gene name
M1R
- Application
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P11229
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Expression Region
210-366aa
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Molecular Weight
20.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
M1R, or the muscarinic acetylcholine receptor subtype 1, is a G protein-coupled receptor that plays a significant role in various physiological processes, particularly in the central nervous system. Its involvement in cognitive functions, such as learning and memory, has made it a focal point of research in neuroscience. M1R's activation is known to modulate neurotransmitter release, influence neuronal excitability, and impact synaptic plasticity, all of which are crucial for higher-order brain functions. Dysregulation of M1R signaling is associated with several neurodegenerative diseases, including Alzheimer's disease, where decreased M1R activity contributes to cognitive decline. Consequently, there is a growing interest in developing M1R-targeted therapeutics, including reconstituted proteins that can mimic M1R's natural signaling pathways. Research on M1R recombinant proteins aims to elucidate its structure-function relationships, understand its role in receptor signaling, and explore potential applications in drug discovery. By studying M1R in a controlled setting, scientists hope to identify new strategies for treating cognitive impairments linked to M1R dysfunction. This research not only enhances our understanding of M1R biology but also holds promise for therapeutic advancements in neurodegenerative disorders.
