Cat: IPD-X28386

Recombinant Human M1R Protein (HEK293),Flag

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Analytical Data

  • 基因名

    M1R

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    Muscarinic acetylcholine receptor M1; CHRM1; Homo sapiens; Human; G-protein coupled receptor; Receptor; Transducer

  • 种属

    Human

  • 表达系统

    HEK293

  • 标签

    Flag

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    P11229-1

  • 表达区间

    M1-A219, S112R, F355-C460

  • 蛋白长度

    Partial

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

M1R, or the muscarinic acetylcholine receptor subtype 1, is a G protein-coupled receptor that plays a significant role in various physiological processes, particularly in the central nervous system. Its involvement in cognitive functions, such as learning and memory, has made it a focal point of research in neuroscience. M1R's activation is known to modulate neurotransmitter release, influence neuronal excitability, and impact synaptic plasticity, all of which are crucial for higher-order brain functions. Dysregulation of M1R signaling is associated with several neurodegenerative diseases, including Alzheimer's disease, where decreased M1R activity contributes to cognitive decline. Consequently, there is a growing interest in developing M1R-targeted therapeutics, including reconstituted proteins that can mimic M1R's natural signaling pathways. Research on M1R recombinant proteins aims to elucidate its structure-function relationships, understand its role in receptor signaling, and explore potential applications in drug discovery. By studying M1R in a controlled setting, scientists hope to identify new strategies for treating cognitive impairments linked to M1R dysfunction. This research not only enhances our understanding of M1R biology but also holds promise for therapeutic advancements in neurodegenerative disorders.

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Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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