Analytical Data
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Gene name
CDX2
- Application
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Alternative Names
CDX3; Homeobox Protein CDX-2; Caudal Type Homeobox Transcription Factor 2
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q99626
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Expression Region
Met1~Gln313
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Molecular Weight
64kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDX2 (Caudal Type Homeobox 2) is a crucial transcription factor involved in the regulation of intestinal development and differentiation. It plays a significant role in maintaining the integrity of the intestinal epithelium and regulating the expression of numerous genes involved in gut function and pathology. Recent studies have highlighted the significance of CDX2 in various gastrointestinal diseases, including colorectal cancer, where aberrant expression of CDX2 has been linked to tumor progression and poor prognosis. The curation of recombinant CDX2 protein has opened new avenues for understanding its biological functions and mechanisms of action in the gut. By producing and studying this protein in vitro, researchers can explore CDX2's interactions with other cellular pathways, its role in transcriptional regulation, and its potential therapeutic implications. Understanding the structure-function relationship of CDX2 and its downstream targets is essential for elucidating the complexities of intestinal biology and developing strategies for treating CDX2-related disorders. Furthermore, CDX2's role as a biomarker for intestinal differentiation makes it a valuable tool in both research and clinical diagnostics. Overall, the study of CDX2 recombinant protein is pivotal for advancing our knowledge of intestinal health and disease, as well as for the development of targeted therapeutic approaches in gastrointestinal disorders.
