Analytical Data
-
Gene name
ATG16L1
- Application
-
Alternative Names
WDR30
-
Species
Human
-
Source
E. coli
-
Tag
N- His & GST
-
Purity
Greater than 95% as determined by SDS-PAGE.
-
Uniprot
Q676U5
-
Expression Region
Met1~Gly284
-
Molecular Weight
63kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ATG16L1 is a crucial protein involved in the process of autophagy, a cellular degradation pathway responsible for maintaining cellular homeostasis by removing damaged organelles and proteins. Research has highlighted the importance of ATG16L1 in both physiological and pathological contexts, particularly in immune responses and inflammatory diseases. It has been implicated in the development of Crohn's disease, a form of inflammatory bowel disease, where mutations in the ATG16L1 gene can lead to impaired autophagic processes and altered gut microbiota. Furthermore, ATG16L1 interacts with other proteins in the autophagic machinery, such as ATG5 and ULK1, leading to a multi-protein complex essential for the formation of autophagosomes. The study of ATG16L1 recombinant proteins has provided insights into the structure-function relationships and regulatory mechanisms of autophagy. Scientists utilize recombinant technology to produce and analyze ATG16L1 in various model systems to understand its role in cellular processes and to explore potential therapeutic targets for related diseases. Overall, research on ATG16L1 not only furthers our understanding of autophagic regulation but also opens up avenues for targeted therapies for diseases linked to dysregulated autophagy.
