Analytical Data
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Gene name
USP9X
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简介
The USP9X protein serves as a deubiquitinase, playing a crucial role in processing ubiquitin precursors and preventing protein degradation. It exhibits specificity in hydrolyzing various polyubiquitin chain linkages, including "Lys-63", "Lys-48", "Lys-29" and "Lys-33". USP9X Protein, Human (GST) is the recombinant human-derived USP9X protein, expressed by E. coli , with N-GST labeled tag.
- Application
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Species
Human
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Source
E. coli
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Tag
N-GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q93008
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Expression Region
K1554-N1995
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Protein Length
Partial
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Molecular Weight
77.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
USP9X (Ubiquitin-Specific Protease 9 X-linked) is a deubiquitinating enzyme that plays a critical role in regulating various cellular processes, including protein stability, signal transduction, and cell cycle progression. Research into USP9X has gained momentum due to its implications in various diseases, particularly cancer and neurodevelopmental disorders. This enzyme is essential for the proper functioning of several signaling pathways, and its dysregulation has been linked to tumorigenesis, making it a potential therapeutic target. Additionally, USP9X has been shown to influence neuronal development and synaptic functions, which has opened avenues for understanding its role in conditions like autism and intellectual disabilities. Given its importance, the production and study of recombinant USP9X protein have become a focus in molecular biology. The recombinant protein allows researchers to investigate the functional mechanisms of USP9X, including its substrate specificity, interaction with other cellular proteins, and its role in disease pathology. By utilizing advanced techniques in protein expression and purification, scientists aim to elucidate the enzymatic activity of USP9X and its potential as a biomarker or drug target, thus enhancing our understanding of its contributions to cellular regulation and disease. Moreover, studying USP9X can provide insights into the broader implications of ubiquitination in cellular homeostasis and disease progression, underscoring its significance in both fundamental and applied biomedical research.
