Analytical Data
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基因名
MOG
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简介
MOG Protein potentially finalizes and maintains the myelin sheath, contributing to cell-cell communication. It acts as a homophilic cell adhesion molecule, mediating cellular interactions through homodimerization, indicating its involvement in establishing connections within myelin-related processes. MOG Protein, Mouse (N-His) is the recombinant mouse-derived MOG protein, expressed by E. coli , with N-His labeled tag.
- Application
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别名
Myelin-oligodendrocyte glycoprotein; Mog; MOGIG2
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种属
Mouse
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q61885
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表达区间
G29-T156
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蛋白长度
Extracellular Domain
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Myelin oligodendrocyte glycoprotein (MOG) is a membrane protein predominantly expressed on the surface of oligodendrocytes, the cells responsible for the formation and maintenance of myelin in the central nervous system (CNS). Research into MOG has gained significant attention due to its potential role in demyelinating diseases, particularly multiple sclerosis (MS). In MS, the immune system mistakenly attacks the myelin sheath surrounding nerve fibers, leading to various neurological symptoms. MOG is a key target for immune cells in this context, making it a crucial focus for understanding the disease mechanisms and developing targeted therapies. The study of recombinant MOG proteins has enabled researchers to investigate its structure, function, and interactions with immune cells, paving the way for therapeutic applications. By generating recombinant MOG, scientists can create specific antibodies and conduct experiments to assess the immune response, contributing to the development of diagnostic tools and treatment strategies for MS and related disorders. Additionally, MOG's involvement in the immune response highlights its potential as a biomarker for early diagnosis and monitoring of disease progression. Overall, MOG research serves as a vital intersection between molecular biology, immunology, and clinical applications, underscoring the importance of understanding this protein in the context of CNS health and disease.
