Analytical Data
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Gene name
IL-10R alpha
- Application
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Alternative Names
CDw210a Interleukin-10 receptor subunit 1 CD_antigen: CD210
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Species
Human
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Source
Yeast
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Tag
N- His & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13651
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Expression Region
22-235aa
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Molecular Weight
28.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-10 receptor alpha (IL-10Rα) is a crucial component of the interleukin-10 signaling pathway, which plays a significant role in regulating immune responses and maintaining homeostasis. IL-10 is an anti-inflammatory cytokine that modulates immune cell functions, promoting tolerance and inhibiting excessive inflammatory responses. Dysfunctional IL-10 signaling is associated with various autoimmune diseases, chronic inflammatory conditions, and even cancer. The study of IL-10Rα has gained attention due to its potential as a therapeutic target; enhancing IL-10 signaling could provide new avenues for treating inflammation-related disorders. Researchers have focused on developing recombinant IL-10Rα proteins for various applications, including characterizing its structure and function, elucidating the mechanisms of IL-10 signaling, and assessing its role as a biomarker. Additionally, these recombinant proteins can be utilized in preclinical and clinical studies to evaluate their efficacy in restoring normal immune function and improving outcomes in patients with inflammatory diseases. Understanding the biology of IL-10Rα and its signaling pathways highlights its importance in immune regulation and underscores the potential for therapeutic innovation in manipulating immune responses.
