Analytical Data
-
Gene name
APEG1
- Application
-
Alternative Names
Aortic preferentially expressed protein 1 ;APEG-1
-
Species
Human
-
Source
E. coli
-
Tag
N- GST
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q15772
-
Expression Region
1-113aa
-
Molecular Weight
38.7 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
APEG1 (also known as APEH1 or AP-endonuclease 1) is a crucial enzyme involved in DNA repair mechanisms, particularly in the base excision repair (BER) pathway. This pathway is essential for maintaining genomic stability by correcting DNA damage caused by oxidative stress, environmental factors, and normal metabolic processes. Aberrant functioning or expression of APEG1 has been linked to various diseases, including cancer, neurodegenerative disorders, and other pathologies characterized by genomic instability. Recent studies have highlighted the importance of APEG1 in cellular responses to DNA damage and its potential as a therapeutic target. Researchers have been focusing on the structural and functional characterization of APEG1, aiming to elucidate its role in both healthy and diseased states. Recombining APEG1 in a laboratory setting allows scientists to investigate its enzymatic activity, substrate affinity, and interactions with other proteins involved in DNA repair. Such research holds promise for developing novel strategies for enhancing DNA repair mechanisms in clinical situations and offers insights into the enzyme's involvement in the cellular response to therapeutic interventions, thereby advancing our understanding of cancer biology and treatment approaches.
