Analytical Data
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Gene name
PAFAHB
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简介
PAFAHB Proteinas, incorporating Alpha-2 adrenergic receptors, facilitates catecholamine-induced adenylate cyclase inhibition through G proteins. Notably, oxymetazoline ranks as the most potent agonist, followed by clonidine and antagonists with yohimbine exhibiting the highest inhibitory activity. This insight into agonist and antagonist effectiveness sheds light on the pharmacological modulation of Alpha-2 adrenergic receptors by ADRA2A-VLPs. PAFAHB Protein, Human (His) is the recombinant human-derived PAFAHB protein, expressed by E. coli , with C-6*His labeled tag.
- Application
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Alternative Names
Platelet-Activating Factor Acetylhydrolase IB Subunit Beta; PAF Acetylhydrolase 30 kDa Subunit; PAF-AH 30 kDa Subunit; PAF-AH Subunit Beta; PAFAH Subunit Beta; PAFAH1B2; PAFAHB
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Species
Human
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Source
E. coli
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P68402
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Expression Region
S2-A229
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AA Sequence
SQGDSNPAAIPHAAEDIQGDDRWMSQHNRFVLDCKDKEPDVLFVGDSMVQLMQQYEIWRELFSPLHALNFGIGGDTTRHVLWRLKNGELENIKPKVIVVWVGTNNHENTAEEVAGGIEAIVQLINTRQPQAKIIVLGLLPRGEKPNPLRQKNAKVNQLLKVSLPKLANVQLLDTDGGFVHSDGAISCHDMFDFLHLTGGGYAKICKPLHELIMQLLEETPEEKQTTIA
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Protein Length
Full Length of Mature Protein
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Molecular Weight
31.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The PAFAHB protein, a member of the family of hydrophilic proteins, has garnered significant interest in the field of biotechnology and molecular biology due to its unique structural and functional properties. Research has shown that PAFAHB plays a crucial role in various biological processes, including cell signaling and protein-protein interactions. The protein is characterized by its ability to fold into a stable conformation, making it an attractive candidate for recombinant protein production. The recombinant expression of PAFAHB has potential applications in the development of therapeutic agents, as it exhibits promising bioactivity, including antimicrobial and anti-inflammatory effects. Additionally, the understanding of its molecular mechanisms can provide valuable insights into disease pathology and the design of targeted therapies. Recent advancements in recombinant DNA technology have facilitated the optimization of PAFAHB production, allowing for increased yield and purity. Furthermore, studies are ongoing to explore its interactions with other biomolecules, which could lead to the identification of novel targets for drug development. Overall, the research on PAFAHB protein offers exciting implications for medical science and biotechnology, paving the way for innovative therapeutic solutions.
