Analytical Data
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Gene name
IFN-gamma R2
- Application
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Biological Activity
Measured by its binding ability in a functional ELISA. When Recombinant Mouse IFN-gamma R1(HY-P72611) is immobilized at 2 μg/mL (100 μL/well), it binds to Recombinant Mouse IFN-gamma R2 in the presence of Recombinant Mouse IFN-gamma(HY-P7071). The ED 50 for this effect is 0.8900 μg/mL. Measured by its binding ability in a functional ELISA. When Recombinant Mouse IFN-gamma R1 (HY-P72611) is immobilized at 2 μg/mL (100 μL/well), it binds to Recombinant Mouse IFN-gamma R2 in the presence of Recombinant Mouse IFN-gamma (HY-P7071). The ED 50 for this effect is 0.8900 μg/mL.
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Alternative Names
Interferon gamma receptor 2; IFN-γ Receptor II; IFNGR2; IFNGT1
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Species
Mouse
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Source
HEK293
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Tag
C-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q63953
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Expression Region
A20-V243
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Protein Length
Partial
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Molecular Weight
40-45 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interferon-gamma (IFN-γ) is a crucial cytokine that plays a significant role in the immune response, particularly in promoting macrophage activation and enhancing antigen presentation. The IFN-γ receptor (IFN-γR) is a heterodimer composed of two subunits, IFN-γR1 and IFN-γR2, with IFN-γR2 primarily serving as the binding component that facilitates signal transduction upon IFN-γ engagement. The study of IFN-γR2, especially in the context of recombinant protein production, has garnered attention due to its potential implications in various diseases, including viral infections, autoimmune disorders, and cancer. By producing IFN-γR2 as a recombinant protein, researchers aim to investigate its structural and functional properties, explore its role in the signaling pathways activated by IFN-γ, and understand its involvement in immune regulation. Furthermore, recombinant IFN-γR2 can serve as a valuable tool in therapeutic applications, potentially leading to novel treatments that modulate immune responses in various pathological conditions. The knowledge gained from these studies can contribute to the development of strategies aimed at enhancing immune responses in infections or suppressing pathological inflammation in autoimmune diseases. Thus, the investigation of IFN-γR2 recombinant protein holds promise for advancing our understanding of immune mechanisms and developing innovative therapeutic approaches.
