Analytical Data
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基因名
IFN-gamma R2
- Application
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生物活性
Measured by its binding ability in a functional ELISA. When Recombinant Mouse IFN-gamma R1(HY-P72611) is immobilized at 2 μg/mL (100 μL/well), it binds to Recombinant Mouse IFN-gamma R2 in the presence of Recombinant Mouse IFN-gamma(HY-P7071). The ED 50 for this effect is 0.8900 μg/mL. Measured by its binding ability in a functional ELISA. When Recombinant Mouse IFN-gamma R1 (HY-P72611) is immobilized at 2 μg/mL (100 μL/well), it binds to Recombinant Mouse IFN-gamma R2 in the presence of Recombinant Mouse IFN-gamma (HY-P7071). The ED 50 for this effect is 0.8900 μg/mL.
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别名
Interferon gamma receptor 2; IFN-γ Receptor II; IFNGR2; IFNGT1
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种属
Mouse
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q63953
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表达区间
A20-V243
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蛋白长度
Partial
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分子量
40-45 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interferon-gamma (IFN-γ) is a crucial cytokine that plays a significant role in the immune response, particularly in promoting macrophage activation and enhancing antigen presentation. The IFN-γ receptor (IFN-γR) is a heterodimer composed of two subunits, IFN-γR1 and IFN-γR2, with IFN-γR2 primarily serving as the binding component that facilitates signal transduction upon IFN-γ engagement. The study of IFN-γR2, especially in the context of recombinant protein production, has garnered attention due to its potential implications in various diseases, including viral infections, autoimmune disorders, and cancer. By producing IFN-γR2 as a recombinant protein, researchers aim to investigate its structural and functional properties, explore its role in the signaling pathways activated by IFN-γ, and understand its involvement in immune regulation. Furthermore, recombinant IFN-γR2 can serve as a valuable tool in therapeutic applications, potentially leading to novel treatments that modulate immune responses in various pathological conditions. The knowledge gained from these studies can contribute to the development of strategies aimed at enhancing immune responses in infections or suppressing pathological inflammation in autoimmune diseases. Thus, the investigation of IFN-γR2 recombinant protein holds promise for advancing our understanding of immune mechanisms and developing innovative therapeutic approaches.
