Analytical Data
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Gene name
Cathepsin W/CTSW
- Application
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Alternative Names
CTS-W; LYPN; Lymphopain
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P56203
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Expression Region
Asp22~Pro371
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Molecular Weight
44kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Cathepsin W (CTSW) is a member of the cysteine cathepsin family, which plays a crucial role in various physiological and pathological processes, including immune responses, inflammation, and cancer progression. Recent studies have highlighted the significance of CTSW in the regulation of immune cell functions, particularly in T cells and dendritic cells, suggesting its potential as a therapeutic target in autoimmune diseases and immunotherapy. Furthermore, CTSW's involvement in the degradation of extracellular matrix components indicates its role in tissue remodeling and metastasis in cancer. The recombinant expression of CTSW protein has garnered attention for its utility in understanding the enzyme's structure, function, and mechanisms of action. Researchers are increasingly focusing on characterizing the biochemical properties of CTSW and its substrate specificity to elucidate its role in disease mechanisms. Additionally, producing recombinant CTSW allows for the development of novel protein-based therapeutics that could modulate its activity, offering potential strategies for treating various diseases linked to dysregulated cathepsin activity. As such, the study of recombinant CTSW not only advances our understanding of cathepsin biology but also opens up avenues for innovative therapeutic interventions.
