Analytical Data
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基因名
IL-2R beta & IL-2R gamma Heterodimer
- Application
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别名
Interleukin-2 receptor subunit beta(IL-2 receptor subunit beta)(IL-2R subunit beta)(IL-2RB)(High affinity IL-2 receptor subunit beta)(p70-75)(CD antigen CD122)
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种属
Cynomolgus
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q38J85
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表达区间
27-240aa
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分子量
28.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-2 receptor (IL-2R) is a crucial component of the immune system, playing a significant role in T-cell proliferation, activation, and survival. The IL-2 receptor is composed of three subunits: alpha (CD25), beta (CD122), and gamma (CD132). The heterodimer formed by the IL-2R beta (CD122) and gamma (CD132) subunits is essential for high-affinity binding of interleukin-2 (IL-2). This heterodimer is particularly important in mediating the effects of IL-2 on immune responses, including the enhancement of T-cell growth and differentiation. In recent years, the recombinant expression of the IL-2R beta and gamma heterodimer has gained attention for its potential applications in therapeutic interventions and immunological studies. By producing this heterodimeric protein in a recombinant system, researchers can investigate its structural and functional properties, as well as its interaction with IL-2 and other cytokines. Understanding the detailed mechanism of IL-2 signaling through this heterodimer can pave the way for designing targeted therapies for autoimmune diseases, cancers, and other immune-related disorders. The development of reliable methods for the production and purification of this recombinant protein is key to advancing the study of IL-2R’s role in immune regulation, providing valuable insights that could lead to novel therapeutic strategies.
