Analytical Data
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Gene name
CHMP6
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简介
The CHMP6 protein is a core component of ESCRT-III and plays a key role in the formation of multivesicular bodies (MVBs) for endosomal cargo protein sorting. MVB is essential for the degradation of membrane proteins transported to lysosomes. CHMP6 Protein, Human is the recombinant human-derived CHMP6 protein, expressed by E. coli , with tag free.
- Application
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Alternative Names
CHMP6; Charged multivesicular body protein 6; Chromatin-modifying protein 6; Vacuolar protein sorting-associated protein 20; Vps20; hVps20
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Species
Human
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96FZ7
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Expression Region
M1-S201
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Protein Length
Full Length
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CHMP6, a crucial component of the ESCRT (endosomal sorting complexes required for transport) pathway, plays a significant role in cellular processes such as multivesicular body formation, endosomal protein sorting, and the maintenance of cellular homeostasis. As a member of the CHMP (charged multivesicular body protein) family, CHMP6 is involved in the recruitment and assembly of ESCRT complexes, which are essential for the recognition and degradation of ubiquitinated proteins in the endosomal-lysosomal pathway. Research into CHMP6 recombinant protein has gained prominence due to its potential implications in understanding various diseases, including neurodegenerative disorders, viral infections, and cancer, where the dysregulation of protein sorting and degradation can lead to pathological conditions. The functional characterization of CHMP6 through recombinant protein studies enables scientists to elucidate its structural properties, interactions with other ESCRT components, and its role in cellular signaling pathways. Additionally, the exploration of CHMP6 as a potential therapeutic target is of growing interest, as manipulating its activity could provide novel strategies for disease intervention. Overall, the study of CHMP6 recombinant protein represents a critical area of research aimed at dissecting the intricate mechanisms of cellular trafficking and their implications in health and disease.
