Analytical Data
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基因名
CHMP6
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简介
The CHMP6 protein is a core component of ESCRT-III and plays a key role in the formation of multivesicular bodies (MVBs) for endosomal cargo protein sorting. MVB is essential for the degradation of membrane proteins transported to lysosomes. CHMP6 Protein, Human is the recombinant human-derived CHMP6 protein, expressed by E. coli , with tag free.
- Application
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别名
CHMP6; Charged multivesicular body protein 6; Chromatin-modifying protein 6; Vacuolar protein sorting-associated protein 20; Vps20; hVps20
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96FZ7
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表达区间
M1-S201
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蛋白长度
Full Length
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CHMP6, a crucial component of the ESCRT (endosomal sorting complexes required for transport) pathway, plays a significant role in cellular processes such as multivesicular body formation, endosomal protein sorting, and the maintenance of cellular homeostasis. As a member of the CHMP (charged multivesicular body protein) family, CHMP6 is involved in the recruitment and assembly of ESCRT complexes, which are essential for the recognition and degradation of ubiquitinated proteins in the endosomal-lysosomal pathway. Research into CHMP6 recombinant protein has gained prominence due to its potential implications in understanding various diseases, including neurodegenerative disorders, viral infections, and cancer, where the dysregulation of protein sorting and degradation can lead to pathological conditions. The functional characterization of CHMP6 through recombinant protein studies enables scientists to elucidate its structural properties, interactions with other ESCRT components, and its role in cellular signaling pathways. Additionally, the exploration of CHMP6 as a potential therapeutic target is of growing interest, as manipulating its activity could provide novel strategies for disease intervention. Overall, the study of CHMP6 recombinant protein represents a critical area of research aimed at dissecting the intricate mechanisms of cellular trafficking and their implications in health and disease.
