Analytical Data
-
Gene name
SLC25A37
-
简介
The SLC25A37 protein is a mitochondrial iron transporter that specifically promotes iron uptake by developing erythrocytes, which is critical for heme biosynthesis. By mediating iron transport into red blood cell mitochondria, SLC25A37 supports heme synthesis, which is critical for various biological processes including hemoglobin formation. SLC25A37 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC25A37 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
- Application
-
Alternative Names
SLC25A37; Mitoferrin-1; Mitochondrial iron transporter 1; Mitochondrial solute carrier protein; Solute carrier family 25 member 37
-
Species
Human
-
Source
Baculovirus
-
Tag
N-MBP;C-Flag;N-8*His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9NYZ2
-
Expression Region
E2-Y338
-
Protein Length
Partial
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SLC25A37, also known as mitochondrial iron transporter 1 (MIT1), plays a critical role in maintaining mitochondrial iron homeostasis and cellular iron metabolism. Dysregulation of iron transport within mitochondria can lead to various pathophysiological conditions, including neurodegeneration, anemia, and mitochondrial diseases. The study of SLC25A37 is essential for understanding the mechanisms underlying these disorders and for developing potential therapeutic strategies. Recent research has focused on the characterization of SLC25A37 through recombinant protein expression, which allows for the investigation of its functional properties, interaction with iron, and transport mechanisms. Recombinant SLC25A37 proteins, produced in suitable expression systems, enable detailed biochemical assays, structural analyses, and functional studies, revealing insights into how this transporter operates at a molecular level. The elucidation of these mechanisms is vital, as it could pave the way for novel interventions targeting mitochondrial iron dysregulation. Current studies emphasize the importance of SLC25A37 in iron metabolism and its potential impact on various diseases, highlighting the need for continued research in this area to uncover the therapeutic potential of targeting SLC25A37 pathways.
