Analytical Data
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Gene name
SLC52A3
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简介
SLC52A3 Protein, a vital plasma membrane transporter, facilitates cellular uptake of vitamin B2/riboflavin, crucial for metabolic reactions. Humans rely on external sources for B2, emphasizing SLC52A3's significance. Vitamin B2 transport, underlining its importance in supporting fundamental metabolic pathways for cellular function and human health. SLC52A3 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC52A3 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
- Application
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Alternative Names
SLC52A3; Solute carrier family 52; riboflavin transporter; member 3; Riboflavin transporter 2; hRFT2
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Species
Human
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Source
Baculovirus
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Tag
N-MBP;C-Flag;N-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NQ40
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Expression Region
A2-A469
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC52A3, a member of the solute carrier family, encodes a protein implicated in the transport of riboflavin (vitamin B2) across cellular membranes. This protein plays a crucial role in vitamin B2 homeostasis, which is essential for various biological processes, including energy metabolism and antioxidant defense. Mutations in the SLC52A3 gene have been linked to inherited disorders such as Brown-Vialetto-Van Laere syndrome (BVVLS) and other forms of riboflavin responsive dystrophies, highlighting its importance in neurodevelopment and neuronal health. Research into the recombinant SLC52A3 protein aims to elucidate its structural and functional properties, which can provide insights into its mechanism of action and regulation in cellular contexts. By expressing the SLC52A3 protein in heterologous systems, scientists can study its transport capabilities, substrate specificity, and interactions with other cellular components. Understanding how SLC52A3 functions may pave the way for developing therapeutic strategies to treat conditions resulting from riboflavin deficiency and further explore its potential role in other pathophysiological conditions, thereby underscoring the necessity for detailed biochemical and pharmacological investigations of this important protein.
