Analytical Data
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Gene name
SLC52A1
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简介
The SLC52A1 protein acts as a plasma membrane transporter, promoting cellular uptake of vitamin B2/riboflavin that is critical for metabolic responses. Humans rely on external sources to obtain B2, which emphasizes its importance. SLC52A1 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC52A1 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
- Application
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Alternative Names
SLC52A1; Solute carrier family 52; riboflavin transporter; member 1; Porcine endogenous retrovirus A receptor 2; PERV-A receptor 2; huPAR-2; Protein GPR172B; Riboflavin transporter 1; hRFT1
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Species
Human
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Source
Baculovirus
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Tag
N-MBP;C-Flag;N-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NWF4
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Expression Region
A2-P448
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC52A1, a member of the solute carrier family, encodes a protein that plays a crucial role in the transport of riboflavin, also known as vitamin B2, across cellular membranes. Mutations in the SLC52A1 gene have been linked to a rare genetic disorder known as riboflavin transporter deficiency (RTD), which is characterized by neurological symptoms, such as ataxia and developmental delays. Research into the SLC52A1 recombinant protein is essential for understanding its functional mechanisms, exploring the pathophysiology of RTD, and developing therapeutic strategies. By producing the SLC52A1 protein in a recombinant system, scientists can study its transport capabilities, assess ligand binding, and investigate its interactions with other cellular components. Additionally, this research facilitates the exploration of potential treatments, such as riboflavin supplementation, and offers insights into the broader implications of riboflavin transport in cellular metabolism and neurological health. As studies continue to reveal the complexities of SLC52A1, it underscores the importance of targeted research in the field of genetic disorders and nutrient transport.
