Analytical Data
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基因名
Kallikrein-15
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简介
Kallikrein-15 is a kallikrein (KLK) with trypsin-like activity that may promote cancer metastasis. The study found that Kallikrein-15 is only strongly expressed in mature sperm cells and not in immature germ cells. KLK15 may be able to cleave many extracellular matrix (ECM) components, interact with the extracellular matrix (ECM) receptor group, and be associated with tumorigenesis. Kallikrein-15 Protein, Human (HEK293, His) is the recombinant human-derived Kallikrein-15 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
ACO protease; KLK15; kallikrein-related peptidase 15
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H2R5-1
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表达区间
Q17-N256
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氨基酸序列
QDGDKLLEGDECAPHSQPWQVALYERGRFNCGASLISPHWVLSAAHCQSRFMRVRLGEHNLRKRDGPEQLRTTSRVIPHPRYEARSHRNDIMLLRLVQPARLNPQVRPAVLPTRCPHPGEACVVSGWGLVSHNEPGTAGSPRSQVSLPDTLHCANISIISDTSCDKSYPGRLTNTMVCAGAEGRGAESCEGDSGGPLVCGGILQGIVSWGDVPCDNTTKPGVYTKVCHYLEWIRETMKRN
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蛋白长度
Full Length of Isoform-1 Mature Protein
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分子量
38-45 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Kallikrein-15 (KLK15) is a member of the kallikrein family of serine proteases, known for their role in various physiological processes including tissue remodeling, inflammation, and hormone regulation. Research into KLK15 has gained significant traction due to its potential implications in cancer biology, particularly breast cancer and other malignancies. This serine protease is thought to be involved in the regulation of the extracellular matrix and may influence tumor progression and metastasis. Additionally, KLK15 has been identified as a biomarker for certain pathological conditions, providing insights into its possible role in disease diagnosis and prognosis. The recombinant production of KLK15 allows for detailed studies into its enzymatic properties, substrate specificity, and functional roles within biological systems. Understanding the mechanisms by which KLK15 operates can lead to novel therapeutic strategies and biomarker development. Furthermore, the exploration of KLK15 may shed light on the broader functions of the kallikrein family in health and disease, highlighting its significance in biomedical research.
