Analytical Data
-
基因名
SLC19A1
-
简介
The SLC19A1 protein acts as an antiporter, importing reduced folate and cyclic dinucleotides by exporting organic anions. It acts as a secondary active transporter, exporting intracellular organic anions to facilitate substrate uptake. SLC19A1 Protein, Human (sf9, His, Strep, FLAG) is the recombinant human-derived SLC19A1 protein, expressed by sf9 insect cells , with N-Strep, C-Flag, N-8*His labeled tag.
- Application
-
别名
SLC19A1; Reduced folate transporter; FOLT; Intestinal folate carrier 1; IFC-1; Placental folate transporter; Reduced folate carrier protein; RFC; hRFC; Reduced folate transporter 1; RFT-1; Solute carrier family 19 member 1; hSLC19A1
-
种属
Human
-
表达系统
Baculovirus
-
标签
N-StrepⅡ;N-8*His;C-Flag
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P41440
-
表达区间
V2-Q591
-
蛋白长度
Partial
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SLC19A1, also known as the solute carrier family 19 member 1, is a key protein involved in the transport of essential vitamins, particularly folate and thiamine, across cell membranes. Its significance lies in its role in maintaining cellular homeostasis and ensuring adequate nutrient supply for various metabolic processes. Dysregulation of SLC19A1 has been implicated in several medical conditions, including neural tube defects, certain types of anemia, and cancer. Recent studies have highlighted its potential as a therapeutic target, prompting extensive research into the structure and function of the SLC19A1 protein. Recombinant SLC19A1 proteins are being produced for various applications, including drug screening, understanding transport mechanisms, and investigating its interactions with ligands and other cellular components. Furthermore, understanding the molecular dynamics of SLC19A1 through recombinant expression allows for insights into how alterations in its activity may contribute to disease states, thereby opening avenues for the development of novel treatments. Overall, the study of SLC19A1 recombinant proteins is vital for elucidating the complexities of nutrient transport and its broader implications in human health.
