Analytical Data
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基因名
EXOSC5
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简介
EXOSC5 is a non-catalytic RNA exosome complex component that is critical in 3'->5' exoribonuclease activity and affects a variety of cellular RNA processing and degradation processes. In the nucleus, it contributes to stable RNA maturation, byproduct elimination, and noncoding transcript degradation. EXOSC5 Protein, Human is the recombinant human-derived EXOSC5 protein, expressed by E. coli , with tag free.
- Application
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别名
EXOSC5; Exosome complex component RRP46; Chronic myelogenous leukemia tumor antigen 28; Exosome component 5; Ribosomal RNA-processing protein 46; p12B
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NQT4
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表达区间
M1-S235
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蛋白长度
Full Length
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EXOSC5, a crucial component of the exonuclease complex, plays a significant role in RNA processing and degradation, influencing various cellular processes such as gene expression, development, and response to stress. Mutations in the EXOSC5 gene have been implicated in diseases like pontocerebellar hypoplasia, underscoring its importance in neurological functions. Given its vital role in maintaining RNA stability and integrity, researchers are increasingly focused on studying EXOSC5 through recombinant protein techniques. These studies aim to elucidate its structural characteristics, functional mechanisms, and interactions with other cellular factors. By producing recombinant EXOSC5, scientists can investigate its enzymatic activity, determine its role in RNA metabolism, and explore its potential as a therapeutic target. Understanding the exact function of EXOSC5 could provide insights into RNA-related disorders and contribute to the development of novel molecular therapies, making it a key focus in molecular biology and biomedicine.
