Analytical Data
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基因名
Glypican-1/GPC1
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简介
Glypican-1 (GPC1) is a heparan sulfate-containing cell surface proteoglycan. Glypican-1/GPC1 Protein, Human (HEK293, His) is the recombinant human-derived Glypican-1/GPC1 protein, expressed by HEK293 , with N-6*His labeled tag.
- Application
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别名
rHuGlypican-1/GPC1, His; Glypican-1; GPC1
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种属
Human
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表达系统
HEK293
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P35052-1
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表达区间
D24-T529
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氨基酸序列
DPASKSRSCGEVRQIYGAKGFSLSDVPQAEISGEHLRICPQGYTCCTSEMEENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQLHPQLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCGNPKVNPQGPGPEEKRRRGKLAPRERPPSGTLEKLVSEAKAQLRDVQDFWISLPGTLCSEKMALSTASDDRCWNGMARGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRSAYNGNDVDFQDASDDGSGSGSGDGCLDDLCSRKVSRKSSSSRTPLTHALPGLSEQEGQKT
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蛋白长度
Partial
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分子量
65-150 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Glypican-1 (GPC1) is a member of the glypican family of heparan sulfate proteoglycans that are attached to the cell membrane through a glycosylphosphatidylinositol (GPI) anchor. It plays a critical role in various cellular processes, including cell signaling, proliferation, and differentiation, by interacting with growth factors and modulating their activity. Recent studies have highlighted the importance of GPC1 in cancer biology, particularly in pancreatic cancer, where it has been implicated in tumor progression and metastasis. Elevated levels of GPC1 have been shown to correlate with poor prognosis, making it a potential biomarker for early diagnosis and a promising target for therapeutic interventions. Research into recombinant GPC1 proteins allows for a deeper understanding of its functional roles and interactions at the molecular level. By producing GPC1 in a recombinant form, scientists can study its structural properties, investigate its role in cell signaling pathways, and explore its potential as a drug target. Additionally, recombinant GPC1 proteins can be used in the development of novel diagnostic tools and therapies aimed at disrupting its function in tumor microenvironments, providing a pathway for innovative cancer treatment strategies. The continued exploration of GPC1's biological functions and its implications in various diseases underscores the significance of recombinant protein research in advancing medical science and improving patient outcomes.
