Analytical Data
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Gene name
KCTD1
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简介
KCTD1 protein is a potential transcriptional regulator that inhibits AP-2 family members (TFAP2A, TFAP2B, TFAP2C). The formation of its homodimer indicates self-association, while the interaction with AP-2 members through the BTB domain emphasizes its role in complex molecular interactions. KCTD1 Protein, Human (sf9) is the recombinant human-derived KCTD1 protein, expressed by sf9 insect cells , with tag free.
- Application
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Alternative Names
KCTD1; BTB/POZ domain-containing protein KCTD1; Potassium channel tetramerization domain-containing protein 1
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Species
Human
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Source
Baculovirus
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q719H9
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Expression Region
S2-D257
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KCTD1 (Potassium Channel Tetramerization Domain-containing Protein 1) is a member of the KCTD protein family, which plays a critical role in various biological processes, including ion channel regulation, signal transduction, and cell proliferation. Recent studies have highlighted KCTD1's involvement in modulating the activity of certain potassium channels, suggesting its significance in maintaining cellular excitability and neuronal function. Aberrant expression or mutations in the KCTD1 gene have been associated with neurological disorders and certain types of cancer, making it a potential therapeutic target. The recombinant expression and purification of KCTD1 protein are essential for the detailed investigation of its structure-function relationship and its interactions with other proteins or ion channels. Utilizing techniques such as expression in bacterial or mammalian systems enables researchers to produce sufficient quantities of the protein for biochemical assays and structural biology studies. Understanding the precise mechanisms by which KCTD1 influences cellular signaling pathways could provide insights into its role in health and disease, paving the way for the development of novel strategies for disease intervention and treatment. As research progresses, KCTD1 continues to be a focus of interest for its potential implications in pharmacology and molecular medicine.
