Analytical Data
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Gene name
KBTBD8
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简介
KBTBD8 in the BCR E3 ubiquitin ligase complex plays a critical regulatory role in neural crest specification. The BCR(KBTBD8) complex coordinates this action by monoubiquitinating NOLC1 and TCOF1. KBTBD8 Protein, Human (sf9, His, Strep) is the recombinant human-derived KBTBD8 protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.
- Application
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Alternative Names
KBTBD8; Kelch repeat and BTB domain-containing protein 8; T-cell activation kelch repeat protein; TA-KRP
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Species
Human
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Source
Baculovirus
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Tag
N-StrepⅡ;N-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NFY9
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Expression Region
A2-L601
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KBTBD8, a member of the Kelch-like BTB (KBT) domain-containing protein family, has garnered attention due to its potential roles in cellular processes such as protein degradation, signal transduction, and cellular stress response. This protein features a BTB domain, which is known to facilitate protein-protein interactions, and a Kelch repeat domain that can interact with various substrates, suggesting its involvement in regulating cellular pathways through ubiquitination and proteasomal degradation mechanisms. Recent studies have indicated that KBTBD8 may play a significant role in the development of certain diseases, including cancer and neurodegenerative disorders, by modulating the turnover of oncogenic or misfolded proteins. Understanding the structure and function of KBTBD8 is essential for elucidating its biological roles and therapeutic potential. This has led to increasing interest in the recombinant expression and characterization of KBTBD8, driven by the need to investigate its molecular interactions, understand its regulatory mechanisms, and explore its potential as a biomarker or therapeutic target. The production of KBTBD8 as a recombinant protein provides a valuable tool for studying its function in various cellular contexts, facilitating the exploration of its role in human diseases and paving the way for potential clinical applications in diagnostics and treatment strategies.
