Analytical Data
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基因名
KBTBD8
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简介
KBTBD8 in the BCR E3 ubiquitin ligase complex plays a critical regulatory role in neural crest specification. The BCR(KBTBD8) complex coordinates this action by monoubiquitinating NOLC1 and TCOF1. KBTBD8 Protein, Human (sf9, His, Strep) is the recombinant human-derived KBTBD8 protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.
- Application
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别名
KBTBD8; Kelch repeat and BTB domain-containing protein 8; T-cell activation kelch repeat protein; TA-KRP
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种属
Human
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表达系统
Baculovirus
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标签
N-StrepⅡ;N-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NFY9
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表达区间
A2-L601
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KBTBD8, a member of the Kelch-like BTB (KBT) domain-containing protein family, has garnered attention due to its potential roles in cellular processes such as protein degradation, signal transduction, and cellular stress response. This protein features a BTB domain, which is known to facilitate protein-protein interactions, and a Kelch repeat domain that can interact with various substrates, suggesting its involvement in regulating cellular pathways through ubiquitination and proteasomal degradation mechanisms. Recent studies have indicated that KBTBD8 may play a significant role in the development of certain diseases, including cancer and neurodegenerative disorders, by modulating the turnover of oncogenic or misfolded proteins. Understanding the structure and function of KBTBD8 is essential for elucidating its biological roles and therapeutic potential. This has led to increasing interest in the recombinant expression and characterization of KBTBD8, driven by the need to investigate its molecular interactions, understand its regulatory mechanisms, and explore its potential as a biomarker or therapeutic target. The production of KBTBD8 as a recombinant protein provides a valuable tool for studying its function in various cellular contexts, facilitating the exploration of its role in human diseases and paving the way for potential clinical applications in diagnostics and treatment strategies.
